Ex vivo evaluation of blood coagulation on endothelial glycocalyx-inspired surfaces using thromboelastography.

ABSTRACT:

Purpose

Present blood-contacting materials have not yet demonstrated to be effective in reducing blood coagulation without causing additional side effects clinically. We have developed an endothelial glycocalyx-inspired biomimetic surface that combines nanotopography, heparin presentation, and nitric oxide (NO)-releasing features. The resulting modified surfaces have already shown promise in reducing unfavorable blood-material interactions using platelet-rich plasma. In this study, the efficacy of modified surfaces for reducing coagulation of human whole blood was measured. In addition, the effects of leached polysaccharides and chemical modification of the modified surfaces were evaluated.

Methods

Leached polysaccharides in the incubation solution were detected by a refract

SUBMITTER: Zang Y 

PROVIDER: S-EPMC11749744 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature