Lipid metabolic remodeling delays senescence of T cells to potentiate their immunity against solid tumors.

ABSTRACT:

Background

Tumor cells can drive the senescence of effector T cells by unbalancing their lipid metabolism, thereby limiting adoptive T cell therapy and contributing to tumor immune evasion. Our objective is to provide a feasible strategy for enhancing T cell treatment efficacy against solid tumors.

Methods

In this study, liposomal arachidonyl trifluoromethyl ketone (ATK) was anchored onto the adoptive T cell surface via bioorthogonal reactions, aiming to specifically inhibit the group IVA cytosolic phospholipase A₂α (cPLA₂α), a key enzyme facilitating phospholipid metabolism and senescent state of T cells.

Results

The surface engineering exerted rare side effects on the activation and migration of T cells, but local and sustained extravasation of

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11749770 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature