Intrauterine metformin exposure and adiposity outcomes in children: a systematic review and meta-analysis.

ABSTRACT:

Objective

The study aims to assess the effect of intrauterine metformin exposure on offspring adiposity measures in childhood.

Design

Systematic review and meta-analysis.

Data sources

Medline, Embase and Cochrane Central were searched from inception to 4 October 2024.

Eligibility criteria for selecting studies

Follow-up studies of randomised-controlled trials and observational studies involving metformin use in pregnancy for any insulin-resistant maternal condition were included.

Data extraction and synthesis

Two reviewers independently extracted data and completed risk-of-bias assessments using either Cochrane Risk-Of-Bias tool V.2 or Risk of Bias in Non-Randomised Studies of Exposure depending on study design. Meta-analyses were conducted using the gen

SUBMITTER: Fu J 

PROVIDER: S-EPMC11749820 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature