Splicing factor PRP-19 regulates mitochondrial stress response.

ABSTRACT: Animals respond to mitochondrial perturbation by activating the mitochondrial unfolded protein response (UPR^mt) to induce the transcription of mitochondrial stress response genes. In Caenorhabditis elegans, activation of UPR^mt allows the animals to maintain organismal homeostasis, activate the innate immune response, and promote lifespan extension. Here, we show that splicing factors such as Precursor RNA processing 19 (PRP-19) are required for the induction of UPR^mt in C. elegans. PRP-19 also modulates mitochondrial perturbation-induced innate immune response and lifespan extension. Knockdown of PRP-19 in mammalian cells suppresses UPR^mt activation and disrupts the mitochondrial network. These findings reveal an evolutionarily cons

SUBMITTER: Xia P 

PROVIDER: S-EPMC11749837 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature