Characterization of the mesenteric circulatory physiology during hemorrhagic shock in a swine model.

ABSTRACT:

Introduction

This study aimed to characterize blood flow through the mesenteric circulation during hemorrhage and resuscitation in a large animal model.

Methods

Five male swine (50-70 kg) underwent anesthesia and placement of flow probes and pressure catheters around and within the superior mesenteric artery, portal vein, and inferior vena cava. A laser doppler flow probe was placed on the intestine to measure end-organ perfusion. Animals were then exsanguinated to a systolic blood pressure of <50mmHg with 60-minutes of shock followed by resuscitation for 120-minutes.

Results

Animals were placed into hemorrhagic shock (lactate peak 5.9 ± 2.1 mmol/L vs baseline: 3.4 ± 0.7 mmol/L) with lower pressures and flows during shock and restoration to baseline following resuscit

SUBMITTER: Treffalls RN 

PROVIDER: S-EPMC11749941 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature