Association between direct oral anticoagulant concentrations and clinical outcomes: A systematic review and meta-analysis.

ABSTRACT:

Introduction

Current guidelines suggest preoperative direct oral anticoagulant levels of < 30-50 ng/ml. However, there is limited evidence to guide this expert consensus. Reviewing assay titres and clinical outcomes may be able to inform perioperative care of the anticoagulated patient. This review aimed to determine whether DOAC assay plasma concentrations are associated with bleeding or systemic embolic events to better appreciate a possible therapeutic or hazardous reference range.

Methods

Systematic search, performed by an information specialist using a peer-reviewed search. Main search concepts were direct oral anticoagulant therapy for atrial fibrillation or venous thromboembolism. Data synthesised in narrative and tabular format whilst data that could be pooled was su

SUBMITTER: Stretton B 

PROVIDER: S-EPMC11749988 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature