Plasma thrombin generation kinetics in trauma patients across the age spectrum.

ABSTRACT:

Background

Injured patients have early changes to normal coagulation that can impact long term risk for thrombotic complications. There is little known about how age impacts biomarkers of coagulation after traumatic injury. In this pilot study, we aimed to characterize thrombin generation kinetics, a known predictor of venous thromboembolism, in trauma patients across the age spectrum.

Methods

Citrated plasma samples were collected from 174 trauma patients (3-94 years old). Thrombin generation kinetics were measured using calibrated automated thrombogram (CAT) and expressed as lag time (LT - minutes) and time to peak (ttPeak - minutes). Kruskal-Wallis, Spearman correlation, and multivariable regression analysis were carried out. Data in median and quartiles [Q1, Q3]. P

SUBMITTER: Goswami J 

PROVIDER: S-EPMC11750001 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature