Light-regulated microRNAs shape dynamic gene expression in the zebrafish circadian clock.

ABSTRACT: A key property of the circadian clock is that it is reset by light to remain synchronized with the day-night cycle. An attractive model to explore light input to the circadian clock in vertebrates is the zebrafish. Circadian clocks in zebrafish peripheral tissues and even zebrafish-derived cell lines are entrainable by direct light exposure thus providing unique insight into the function and evolution of light regulatory pathways. Our previous work has revealed that light-induced gene transcription is a key step in the entrainment of the circadian clock as well as enabling the more general adaptation of zebrafish cells to sunlight exposure. However, considerable evidence points to post-transcriptional regulatory mechanisms, notably microRNAs (miRNAs), playing an essential role in shaping d

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11750094 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature