Dengue severity by serotype and immune status in 19 years of pediatric clinical studies in Nicaragua.

ABSTRACT:

Background

Dengue virus, a major global health threat, consists of four serotypes (DENV1-4) that cause a range of clinical manifestations from mild to severe and potentially fatal disease.

Methods

This study, based on 19 years of data from the Pediatric Dengue Cohort Study and Pediatric Dengue Hospital-based Study in Managua, Nicaragua, investigates the relationship of serotype and immune status with dengue severity. Dengue cases were confirmed by molecular, serological, and/or virological methods, and study participants 6 months to 17 years old were followed during their hospital stay or as ambulatory patients.

Results

We enrolled a total of 15,833 participants, of whom 3,308 (21%) were positive for DENV infection. Of 2,644 cases with serotype result by RT-PCR, 559 c

SUBMITTER: Narvaez F 

PROVIDER: S-EPMC11750095 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature