Widespread release of translational repression across Plasmodium's host-to-vector transmission event.

ABSTRACT: Malaria parasites must respond quickly to environmental changes, including during their transmission between mammalian and mosquito hosts. Therefore, female gametocytes proactively produce and translationally repress mRNAs that encode essential proteins that the zygote requires to establish a new infection. While the release of translational repression of individual mRNAs has been documented, the details of the global release of translational repression have not. Moreover, changes in the spatial arrangement and composition of the DOZI/CITH/ALBA complex that contribute to translational control are also not known. Therefore, we have conducted the first quantitative, comparative transcriptomics and DIA-MS proteomics of Plasmodium parasites across the host-to-vector transmission event to docum

SUBMITTER: Rios KT 

PROVIDER: S-EPMC11750109 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature