Endopiriform neurons projecting to ventral CA1 are a critical node for recognition memory.

ABSTRACT: The claustrum complex is viewed as fundamental for higher-order cognition; however, the circuit organization and function of its neuroanatomical subregions are not well understood. We demonstrated that some of the key roles of the CLA complex can be attributed to the connectivity and function of a small group of neurons in its ventral subregion, the endopiriform (EN). We identified a subpopulation of EN neurons by their projection to the ventral CA1 (EN^vCA1-proj. neurons), embedded in recurrent circuits with other EN neurons and the piriform cortex. Although the EN^vCA1-proj. neuron activity was biased toward novelty across stimulus categories, their chemogenetic inhibition selectively disrupted the memory-guided but not innate responses of mice to novelty. Based on ou

SUBMITTER: Yamawaki N 

PROVIDER: S-EPMC11750136 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature