Recommendations for reporting and evaluating proton therapy beyond dose and constant relative biological effectiveness.

ABSTRACT:

Background and purpose

In proton therapy, a relative biological effectiveness (RBE) of 1.1 is used to convert proton dose into an equivalent photon dose. However, RBE varies with tissue type, fraction dose, and beam quality parameters beyond dose such as linear energy transfer (LET) raising concerns about increased local effectiveness and potential toxicity. This work aims to harmonize quantities used for clinical consideration of variable RBE for proton therapy.

Materials and methods

A survey was distributed to proton centres to determine agreement on RBE-related concerns and clinical implementations. A subsequent clinical expert meeting facilitated by the European Particle Therapy Network was held to achieve consensus and to make clinical recommendations how to prescribe a

SUBMITTER: Luhr A 

PROVIDER: S-EPMC11750264 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature