Chemokine associations with blood cerebrospinal fluid (CSF) barrier permeability and delirium.

ABSTRACT: Delirium is a highly prevalent neuropsychiatric syndrome characterised by acute and fluctuating impairments in attention and cognition. Mechanisms driving delirium are poorly understood but it has been suggested that blood cytokines and chemokines cross the blood brain barrier during delirium, directly impairing brain function. It is not known whether these molecules reach higher brain levels when the blood cerebrospinal fluid barrier (BCSFB) is impaired. Here, in human hip-fracture patients, we tested the influence of BCSFB integrity on CSF levels of chemokines and assessed their association with delirium. CSF levels of IP-10, eotaxin, eotaxin 3 and TARC showed weak to moderate correlations with BCSFB permeability, as measured by the Q_albumin ratio, while MCP1, IL-8, MIP1α and

SUBMITTER: Denver P 

PROVIDER: S-EPMC11750293 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature