Telomeric RNA quadruplexes as targets for cancer prevention: The therapeutic potential of agonodepsides.

ABSTRACT:

Background

Cancer remains an awful challenge, despite years of targeting proteins to control its relentless growth and spread. Fungal metabolites, a treasure of natural chemicals, offer a glimmer of hope. Telomeres, the cellular "caps," are a focal point in cancer research. This study explores the potential of stabilizing Telomeric Repeats-containing RNA G-quadruplex (TERRA G4) structures within telomeres. This stabilization could block telomerase, the enzyme that repairs telomeres, and potentially trigger cancer cell death. Agonodepsides A and B, two promising fungal metabolites, were chosen to investigate this exciting possibility.

Methods

Agonodepside A and B were initially screened for drug likeness employing SwissAdme. AutoDock Vina was used for molecular docking, and l

SUBMITTER: Choudhir G 

PROVIDER: S-EPMC11750472 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature