Spirometric pattern and cardiovascular risk: a prospective study of 0.3 million Chinese never-smokers.

ABSTRACT:

Background

Existing studies have not provided robust evidence about the CVD risk of non-smoking patients with restrictive spirometric pattern (RSP) or airflow obstruction (AFO), and how the risk is modified by body shape. We aimed to bridge the gap.

Methods

We used never-smokers' data from the China Kadoorie Biobank (CKB) and performed Cox models by sex (278,953 females and 50,845 males). Spirometry was used to assess the baseline spirometric pattern. CVD outcomes were captured through multiple sources.

Findings

Females' results were presented primarily, though males' results were similar. During a median 12-year (maximum 14.5 years) follow-up, both RSP and AFO patients had increased risks of acute myocardial infarction (AMI), other ischaemic heart disease (other IHD)

SUBMITTER: Ding Y 

PROVIDER: S-EPMC11750506 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature