Genetic predisposition to Behcet's disease mediated by a IL10RA enhancer polymorphism.

ABSTRACT:

Background

Several studies suggested the genetic association between IL10RA variants and susceptibility to Behcet's disease (BD). However, the precise mechanism of the association is still unknown. The purpose of this study was to investigate the mechanism underlying the genetic associations between IL10RA polymorphisms and the risk of BD.

Methods

To analyse the genetic susceptibility to BD mediated by IL10RA causal polymorphisms, we performed a study on data from our previous genome-wide association studies (GWAS), the bioinformatic analysis of post-annotation of GWAS and relevant mechanism verification experiments, including chromatin immunoprecipitation, luciferase gene-reporter assay, electrophoretic mobility shift assays, and enzyme-linked immunosorbent assay.

Result

SUBMITTER: Tan H 

PROVIDER: S-EPMC11750533 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature