Acute high-intensity interval exercise is superior to moderate-intensity continuous exercise in enhancing endothelial function and its associated biomarkers in sedentary young individuals: the possible involvement of lactate.

ABSTRACT:

Objectives

Our study investigated the effects of acute high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) on endothelial function and its associated biomarkers in sedentary young individuals.

Methods

Fifteen subjects (10M / 5F; 22 ± 2 years; BMI: 23.07 ± 4.12 kg/m²) participated in a crossover trial including three experimental conditions: HIIE, MICE, and a control session of rest (CON) in random order separated by a 7-day washout period. Endothelial function was assessed using flow-mediated dilation (FMD), mean shear rate (MSR), and circulating levels of blood lactate, VEGF, IGF-1, and irisin.

Results

Both HIIE and MICE significantly enhanced FMD% (both P < 0.001 and P < 0.01, respectively), lactate (bot

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11750549 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature