Gradient disparities in allergy and the gut microbiome among rural, migrant, and urban populations across China.

ABSTRACT:

Background

While much of the evidence linking the rapid urbanization and the increasing prevalence of allergen sensitization, but little is known regarding rural-to-urban migrants. The aim of this study was to identify the disparities in allergy, the gut microbiome and factors among native urban, migrating, and native rural Chinese.

Methods

We redesigned the dataset of the China Alliance of Research on Respiratory Allergic Disease secondary survey, and after stratified sampling, a subsample of 2422 subjects were enrolled for the analysis of a questionnaire, skin prick tests (SPT), and specific immunoglobulin E (sIgE) titer measurements against 8 common allergens. Fecal microbiotal composition was also sequenced by 16S rRNA and regression-based analyses with covariate adjustm

SUBMITTER: Wang W 

PROVIDER: S-EPMC11750550 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature