Genetic association of lipid and lipid-lowing drug targets with uterine fibroids.

ABSTRACT:

Objective

Observational studies suggest that blood lipids are a risk factor for uterine fibroids (UFs) and that lipid-lowering drugs are beneficial for the treatment and prevention of UF; however, the conclusions are inconsistent. We aimed to determine the causal effects of lipids and lipid-lowering drugs on UFs using Mendelian randomization (MR).

Methods

Genetic variants from genome-wide association studies (GWAS) of lipid traits and variants in genes encoding lipid-lowering drug targets were extracted, and two independent UF GWAS were set as the outcome. Their effects on UF risk and related traits were estimated using the inverse variance weighted method.

Results

The MR analysis revealed that high density lipoprotein cholesterol (HDL-C, OR = 0.88, 95 % CI: 0.83-0.93

SUBMITTER: Wu M 

PROVIDER: S-EPMC11750556 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature