Therapies Used by Children With Primary Ciliary Dyskinesia: A Natural History Study.

ABSTRACT:

Introduction

Primary ciliary dyskinesia (PCD) management has not been systematically evaluated and is largely empirical.

Methods

Pediatric participants with PCD were enrolled in a prospective, longitudinal, multicenter, observational study. Therapies were recorded at annual visits and categorized by type. Age-related trends in prevalence of therapies were described by serial cross-sectional analyses. Generalized estimating equations analyzed covariates affecting prevalence of certain therapies and whether these covariates impacted oral antibiotic courses.

Results

A total of 137 participants completed 897 visits over 13 years. All but one received ≥ 1 antibiotic courses during study participation, most often cephalosporins (74%) or amoxicillin-clavulanate (73%). Thirty

SUBMITTER: Gardner RA 

PROVIDER: S-EPMC11750599 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature