Siblings' similarity in neural responses to loss reflects mechanisms of familial transmission for depression.

ABSTRACT: Having a depressed first-degree relative is one of the most replicated risk factors for depression. Research on the familial transmission of depression, however, has largely ignored siblings, even though sibling relationships are commonplace and characterized by frequent and intense emotions. It has been suggested that frequent contacts in close relationships lead to similarities in emotions and cognitions over time, a process underpinned by biobehavioral synchrony. Consequently, to shed light on the neural mechanism underlying familial transmission of depression, the present study tested whether neural similarity in response to reward and loss, indexed by inter-subject correlation (ISC), was associated with major depressive disorder (MDD) diagnosis, depression symptom severity, and relati

SUBMITTER: Li LY 

PROVIDER: S-EPMC11750602 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature