Tregs levels and phenotype modifications during Amyotrophic Lateral Sclerosis course.

ABSTRACT:

Introduction

T regulatory cells (Tregs) inversely correlate with disease progression in Amyotrophic Lateral Sclerosis (ALS) and fast-progressing ALS patients have been reported to exhibit dysfunctional, as well as reduced, levels of Tregs. This study aimed to evaluate the longitudinal changes in Tregs among ALS patients, considering potential clinical and biological modifiers of their percentages and concentrations. Additionally, we explored whether measures of ALS progression, such as the decline over time in the revised ALS Functional Rating Scale (ALSFRS-r) or forced vital capacity (FVC) correlated Treg levels and whether Treg phenotype varied during the course of ALS.

Methods

Total Tregs (detected by CD3, CD4, FoxP3, CD25, and CD127) were quantified at five time points o

SUBMITTER: Zucchi E 

PROVIDER: S-EPMC11750661 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature