Hypercholesterolemia triggers innate immune imbalance and transforms brain infarcts after ischemic stroke.

ABSTRACT: Post-stroke early activation of neutrophils contributes to intensive neuroinflammation and worsens disease outcomes. Other pre-existing patient conditions can modify the extent of their activation during disease, especially hypercholesterolemia. However, whether and how increased circulating cholesterol amounts can change neutrophil activation responses very early after stroke has not been studied. In this study, we investigated the effect of high-fat diet (HFD) induced hypercholesterolemia on neutrophil activation and stroke outcome. Mice were fed with HFD or normal diet (ND) for six weeks and then induced stroke by transient occlusion of the middle cerebral artery. The activation receptors on immune cells and plasma levels of cytokines were analyzed using flow cytometry. The amount of pl

SUBMITTER: Tuz AA 

PROVIDER: S-EPMC11750678 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature