StormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments.

ABSTRACT:

Introduction

Tuberculosis (TB) poses a significant threat to global health, with millions of new infections and approximately one million deaths annually. Various modeling efforts have emerged, offering tailored data-driven and physiologically-based solutions for novel and historical compounds. However, this diverse modeling panorama may lack consistency, limiting result comparability. Drug-specific models are often tied to commercial software and developed on various platforms and languages, potentially hindering access and complicating the comparison of different compounds.

Methods

This work introduces stormTB: SimulaTOr of a muRine Minimal-pbpk model for anti-TB drugs. It is a web-based interface for our minimal physiologically based pharmacokinetic (mPBPK) platform, desi

SUBMITTER: Visintainer R 

PROVIDER: S-EPMC11750688 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature