Rat models of postintracerebral hemorrhage pneumonia induced by nasal inoculation with <i>Klebsiella pneumoniae</i> or intratracheal inoculation with LPS.

ABSTRACT:

Background

A stable and reproducible experimental bacterial pneumonia model postintracerebral hemorrhage (ICH) is necessary to help investigating the pathogenesis and novel treatments of Stroke-associated pneumonia (SAP).

Aim

To establish a Gram-negative bacterial pneumonia-complicating ICH rat model and an acute lung injury (ALI)-complicating ICH rat model.

Methods

We established two standardized models of post-ICH pneumonia by nasal inoculation with Klebsiella pneumoniae (Kp) or intratracheal inoculation with lipopolysaccharide (LPS). Survival and neurological scores were monitored. Magnetic resonance imaging was performed to evaluate hematoma volume. Abdominal aortic blood was collected for leukocyte counting, serum was isolated to determine concentra

SUBMITTER: Wang R 

PROVIDER: S-EPMC11750689 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature