Magnetoelectric nanodiscs enable wireless transgene-free neuromodulation.

ABSTRACT: Deep brain stimulation with implanted electrodes has transformed neuroscience studies and treatment of neurological and psychiatric conditions. Discovering less invasive alternatives to deep brain stimulation could expand its clinical and research applications. Nanomaterial-mediated transduction of magnetic fields into electric potentials has been explored as a means for remote neuromodulation. Here we synthesize magnetoelectric nanodiscs (MENDs) with a core-double-shell Fe₃O₄-CoFe₂O₄-BaTiO₃ architecture (250 nm diameter and 50 nm thickness) with efficient magnetoelectric coupling. We find robust responses to magnetic field stimulation in neurons decorated with MENDs at a density of 1 µg mm^-2 despite individual-particle pote

SUBMITTER: Kim YJ 

PROVIDER: S-EPMC11750723 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature