Combined endurance and resistance exercise training in heart failure with preserved ejection fraction: a randomized controlled trial.

ABSTRACT: Endurance exercise training (ET) is an effective treatment in heart failure with preserved ejection fraction (HFpEF), but the efficacy of resistance training in this patient population has been only scarcely evaluated. In this multicenter, randomized trial, we evaluated the effects of combined endurance and resistance training over 12 months in patients with HFpEF. The primary endpoint was a modified Packer score, including all-cause mortality, hospitalizations classified as potentially related to heart failure or exercise and changes in peak oxygen consumption ( V̇O2 ), diastolic function (E/e'), New York Heart Association (NYHA) class and global self-assessment (GSA). In total, 322 patients (mean age, 70 years; 192 females (59.6%) and 130 males (40.4%)) were randomized (1:1) to ET or usu

SUBMITTER: Edelmann F 

PROVIDER: S-EPMC11750725 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature