Peritoneal chemotherapy delivery systems for ovarian cancer treatment: systematic review of animal models.

ABSTRACT:

Introduction

Intraperitoneal chemotherapy for ovarian cancer treatment has controversial benefits as most methodologies are associated with significant morbidity. We carried out a systematic review to compare tumor response, measured by tumor weight and volume, between intraperitoneal chemotherapy delivered via drug delivery systems (DDSs) and free intraperitoneal chemotherapy in animal models of ovarian cancer. The secondary aim was to assess the toxicity of DDS-delivered chemotherapy, based on changes in animal body weight.

Methods

Based on PRISMA and SYRCLE guidelines, we identified 38 studies for review, of which 20, were used in the meta-analysis. We evaluated outcome, through tumor volume and tumor weight and, toxicity, through animal weight. Analysis was based on drug

SUBMITTER: Simonsen M 

PROVIDER: S-EPMC11750819 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature