Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer.

ABSTRACT:

Backgrounds

Collagen type I alpha 1 chain (COL1A1) is a key protein encoding fibrillar collagen, playing a crucial role in the tumor microenvironment (TME) due to its complex functions and close association with tumor invasiveness. This has made COL1A1 a focal point in cancer biology research. However, studies investigating the relationship between COL1A1 expression levels and clinical characteristics of ovarian cancer (OC) remain limited.

Methods

This study integrated resources from publicly available online databases and immunohistochemistry (IHC) techniques to analyze and validate COL1A1 expression in OC tissues, and evaluated its potential association with clinical features in OC patients. The prognostic value of COL1A1 was assessed using Kaplan-Meier (KM) survival curve

SUBMITTER: Xiao X 

PROVIDER: S-EPMC11750837 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature