Photodynamic therapy with a novel photosensitizer inhibits DSS-induced ulcerative colitis in rats via the NF-κB signaling pathway.

ABSTRACT:

Introduction

Ulcerative colitis (UC) is an inflammatory bowel disease characterized by inflammation and ulceration of the digestive tract.

Methods

Photodynamic therapy (PDT) with a novel photosensitizer LD₄ was used to treat UC rat models to explore the therapeutic effect and mechanism of LD₄-PDT on UC. 16S ribosomal RNA was used to detect the composition of Gut microbiota.

Results

Our findings indicate that LD₄-PDT could protect the integrity of the colonic mucosa, alleviate the inflammatory response and promote the healing of colonic mucosa. Mechanism studies demonstrated that LD₄-PDT could inhibit the NF-κB signaling pathway, downregulated the expression of the inflammatory factors' tumor necrosis factor-α (TNF-α),

SUBMITTER: Rong Y 

PROVIDER: S-EPMC11750845 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature