Viral infections of the central nervous system increase the risk of knee osteoarthritis: a two-sample mendelian randomization study.

ABSTRACT:

Objective

Osteoarthritis (OA) represents a condition under the influence of central nervous system (CNS) regulatory mechanisms. This investigation aims to examine the causal association between viral infections of the central nervous system (VICNS) and inflammatory diseases of the central nervous system (IDCNS) and knee osteoarthritis (KOA) at the genetic level.

Methods

In this investigation, VICNS and IDCNS were considered as primary exposure variables, while KOA served as the primary outcome. Employing a two-sample mendelian randomization (MR) approach, we conducted an analysis utilizing summary data derived from genome-wide association studies (GWAS). The GWAS summary data pertaining to VICNS and IDCNS were procured from the Finnish consortium, whereas the IEU OpenGWAS da

SUBMITTER: Yang M 

PROVIDER: S-EPMC11750930 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature