Causal analysis of dietary preferences and the risk of endometriosis using large-scale population data.

ABSTRACT: Dietary factors have recently been recognized as potentially influential in the pathogenesis of endometriosis (EM), yet studies on the causal relationship between dietary preferences and EM are limited. The present study aimed to explore the causal relationships between 187 dietary preferences and EM using Mendelian randomization (MR) methods. This study utilised genome-wide association study data from over 500,000 European participants for dietary preferences and 64,658 EM patients from Finland. Dietary preferences with potential causal relationships to EM were identified using two-sample MR methods. P-values from the inverse variance weighted (IVW) analysis were corrected using the false discovery rate (FDR) method to ensure accuracy. Additionally, heterogeneity analysis, pleiotropy asse

SUBMITTER: Cheng X 

PROVIDER: S-EPMC11750975 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature