PCDH17 induces colorectal cancer metastasis by destroying the vascular endothelial barrier.

ABSTRACT: Compromised vascular integrity facilitates the cancer cells extravasation and metastasis. However, the mechanisms leading to a disruption in vascular integrity in colorectal cancer (CRC) remain unclear. In this study, PCDH17 expression was higher in the vascular endothelial cells of colon cancer with distant metastasis, and the rates of PCDH17⁺ endothelial cells (ECs) was associated with the M stage in clinical pathological characteristics analysis and correlated with a poor survival prognosis. The liver and lung metastatic dissemination of MC-38 was significantly decreased in PCDH17^-/-mice. The ubiquitination and degradation of VEGFR2 was prevented by the interaction between PCDH17 and the E3 ubiquitin ligase MARCH5, which causing the separation of internalized VE-ca

SUBMITTER: Dong F 

PROVIDER: S-EPMC11750977 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature