Gradient coating of extracellular matrix derived from endothelial cells on aligned PCL nanofibers for rapid endothelialization.

ABSTRACT:

Introduction

Artificial vascular scaffolds can mimic the structure of natural blood vessels and replace the damaged vessels by implanting them at the injury site to perform the corresponding functions. Electrospinning technology can perfectly combine biological signals and topographical cues to synergistically induce directed cell migration and growth.

Methods

In this study, poly (caprolactone) (PCL) nanofibers, PCL nanofibers uniformly coated with the extracellular matrix derived from endothelial cells (ECd), and bi-directional linear gradient ECd-coated PCL nanofibers were prepared by electrospinning and electrospray techniques to evaluate their effects on the proliferation and migration of Human umbilical vein endothelial cells (HUVECs) and rapid endothelialization.

Re

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC11751034 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature