Integrated analysis of genetic, proteinic, and metabolomic alterations in Behcet's disease.

ABSTRACT: Numerous studies have investigated the alterations of genes, proteins, and metabolites in Behcet's disease (BD). By far, little is known about the depiction of panoramic changes underlying this disease. This study purposed to assess the consistently dysregulated genes, proteins, and metabolites in BD across publications using the vote-counting approach. This study was based on 745 studies that identified a collection of 2354 differential molecules with 3574 molecule entries in blood, peripheral blood mononuclear cells, CD4⁺T cells, and aqueous humor samples from patients with BD. In this study, the results of binomial analysis showed that the circulating levels of 38 molecules, including interferon-γ and interleukin 17, were consistently upregulated, whereas high density lipopro

SUBMITTER: Pu Y 

PROVIDER: S-EPMC11751112 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature