Association of optic disc drusen and small scleral canals - A systematic review and meta-analysis.

ABSTRACT: The pathophysiology of optic disc drusen (ODD) has long been discussed. According to one leading theory, they develop from calcified mitochondria extruded from axons compressed by an unusually small scleral canal. To examine this hypothesis, we conducted a systematic review and meta-analysis evaluating the scleral canal size in patients with ODD (PO) in comparison to healthy subjects (HS). We searched MEDLINE, Cochrane Central, EMBASE and gray literature to identify relevant articles. A subgroup analysis compared patients with buried ODD (PO_b) and patients with visible ODD (PO_v). The study was registered with the International Prospective Register of Systematic Reviews on December 9th, 2022 (Registration: CRD42022375110). We included fifteen articles in the review and

SUBMITTER: Vienne-Jumeau A 

PROVIDER: S-EPMC11751152 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature