Multifactorial approach is needed to unravel the maturation phases of human neurons derived from induced pluripotent stem cells.

ABSTRACT: Neurons derived from induced pluripotent stem cells (h-iPSC-Ns) provide an invaluable model for studying the physiological aspects of human neuronal development under healthy and pathological conditions. However, multiple studies have demonstrated that h-iPSC-Ns exhibit a high degree of functional and epigenetic diversity. Due to the imprecise characterization and significant variation among the currently available maturation protocols, it is essential to establish a set of criteria to standardize models and accurately characterize and define the developmental properties of human neurons derived from iPSCs. In this study, we conducted comprehensive cellular and network level analysis of the functional development of human neurons, generated from iPSCs obtained from healthy young female per

SUBMITTER: Ben Mahmoud M 

PROVIDER: S-EPMC11751176 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature