Causal role of ischemic heart disease in ovarian cancer subtypes.

ABSTRACT:

Background

Ischemic heart disease (IHD) may share biological mechanisms with cancer, including ovarian cancer, through pathways such as chronic inflammation and oxidative stress. However, the relationship between IHD and ovarian cancer subtypes remains unclear. This study used Mendelian randomization (MR) to explore potential causal associations.

Methods

A two-sample MR analysis was conducted using genetic instruments for IHD from large-scale genome-wide association studies (GWAS). The inverse-variance weighted (IVW) method was used as the primary analysis, supported by MR-Egger, weighted median, and MR-PRESSO for sensitivity analyses.

Results

No significant association was found between IHD and overall ovarian cancer risk (OR = 0.97, 95% CI 0.92-1.03, P = 0.378). How

SUBMITTER: Chen J 

PROVIDER: S-EPMC11751212 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature