PLK3 weakens antioxidant defense and inhibits proliferation of porcine Leydig cells under oxidative stress.

ABSTRACT: Aging is characterized by cellular degeneration and impaired physiological functions, leading to a decline in male sexual desire and reproductive capacity. Oxidative stress (OS) lead to testicular aging by impairing the male reproductive system, but the potential mechanisms remain unclear. In the present study, the functional status of testicular tissues from young and aged boars was compared, and the transcriptional responses of Leydig cells (LCs) to hydrogen peroxide (H₂O₂)-induced senescence were explored, revealing the role of OS in promoting aging of the male reproductive system. 601 differentially expressed genes (DEGs) associated with OS, cell cycle regulation, and intracellular processes were identified. These DEGs were significantly enriched in critical aging

SUBMITTER: Chen C 

PROVIDER: S-EPMC11751325 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature