Changes in platelet maturity and reactivity following acute ST-segment elevation myocardial infarction.

ABSTRACT:

Background

Reduced effect of antiplatelet therapy has been reported in patients with ST-segment elevation myocardial infarction (STEMI). This could partly be explained by an increase of highly reactive immature platelets.

Objectives

To investigate changes in platelet maturity and reactivity after acute STEMI.

Methods

Patients diagnosed with STEMI, admitted for primary percutaneous coronary intervention, and treated according to international guidelines, were included. Blood samples were obtained within 24 hours after admission and at 2- to 3-months follow-up. Platelet maturity and reactivity using multicolor flow cytometry with SYTO-13 to categorize platelet maturity, whole blood platelet aggregation, serum thromboxane B2 levels, and standard immature platelet markers

SUBMITTER: Pedersen OB 

PROVIDER: S-EPMC11751529 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature