Impact of Surgical Margin Status and Tumor Volume on Mortality After Robotic Radical Prostatectomy.

ABSTRACT:

Background and objective

Positive surgical margins (PSMs) following radical prostatectomy (RP) have been seen as inherently unfavorable. However, a large international multi-institutional study recently revealed that unifocal PSMs (UPSMs) had no impact on prostate cancer-specific mortality (PCSM), whereas multifocal PSMs (MPSMs) did. Our aim was to assess the relative impact of PSMs versus percentage tumor volume (PTV) on PCSM.

Methods

We analyzed data for 1552 patients who underwent robot-assisted RP performed by a single surgeon between 2002 and 2018 at a tertiary referral center with up to 15-yr follow-up. Patients were divided into negative surgical margin (NSM), UPSM, and MPSM groups, with PTV stratification using a cutoff of 40%. The primary outcome was stepwise multiv

SUBMITTER: Zeidan Z 

PROVIDER: S-EPMC11751535 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature