Suicide and suicide attempt in users of GLP-1 receptor agonists: a nationwide case-time-control study.

ABSTRACT:

Background

Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are extensively evaluated for the risk of suicidal behaviors or ideation; the influence of psychiatric history or obesity on this potential effect remains to be investigated. Therefore, we aimed to assess the association between GLP-1 RA and suicide or suicide attempt, considering these factors.

Methods

Patients ≥18 y who died by suicide or were hospitalized for suicide attempt (2013-2021) with at least one GLP-1 RA dispensing within the 180 preceding days were selected from the French National Health Data System (SNDS). A case-time-control design compared, for each patient, GLP-1 RA exposure in the 30 days preceding the outcome (composite of suicide or suicide attempt) to three earlier 30-day reference periods.

SUBMITTER: Bezin J 

PROVIDER: S-EPMC11751538 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature