Eicosapentaenoic acid as an antibiofilm agent disrupts mature biofilms of Candida albicans.

ABSTRACT: The biofilm formation of Candida albicans, a major human fungal pathogen, represents a crucial virulence factor during candidiasis. Eicosapentaenoic acid (EPA), a polyunsaturated fatty acid, has emerged as a potential antibiofilm agent against C. albicans. Herein, we aim to investigate the antifungal effect of EPA (1 mM) on the mature biofilm of C. albicans and explore the underlying mechanism. Crystal violet and XTT assays showed that EPA exerted a strong inhibitory efficacy on preformed biofilms in C. albicans. Biofilm architecture and cell viability were observed using scanning electron microscopy and confocal laser scanning microscopy, indicating that EPA could block the yeast-to-hypha transition and damage the structure, thereby exhibiting antibiofil

SUBMITTER: Wang S 

PROVIDER: S-EPMC11751545 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature