Prognostic significance of p27 in colorectal cancer: a meta-analysis and bioinformatics analysis.

ABSTRACT:

Background

In the past, numerous investigations have delved into the influence of p27 (p27kip) on the prognosis and clinicopathological characteristics of colorectal cancer (CRC), yielding conclusions that are not universally statistically significant, thus rendering the discourse rather contentious.

Methods

We collected available articles published before August 2024 and extracted data to analyze the association between the expression of p27 and the prognosis and clinicopathological features of CRC. In addition, we used Gene Expression Profiling Interactive Analysis (GEPIA), University of Alabama at Birmingham's Cancer Data Analysis Portal (UALCAN), and the Human Protein Atlas (HPA) to validate our results.

Results

Through an extensive examination of four prominent d

SUBMITTER: Zou J 

PROVIDER: S-EPMC11751620 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature