Use of Albumin-Adjusted Calcium Measurements in Clinical Practice.

ABSTRACT:

Importance

Using albumin-adjusted calcium is commonly recommended for for measuring calcium, but with little empirical evidence to support the practice.

Objective

To assess the correlation between total calcium measurements (with or without adjustment) vs the ionized calcium level as a reference standard.

Design, setting, and participants

This was a population-based cross-sectional study in the province of Alberta, Canada, including adults tested for serum total calcium and ionized calcium simultaneously between January 1, 2013, and October 31, 2019. Statistical analysis was performed from March 2023 to October 2024.

Main measures and outcomes

The correlation between unadjusted and adjusted total calcium measurements (using 10 formulas) and the ionized calcium

SUBMITTER: Desgagnes N 

PROVIDER: S-EPMC11751745 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature