Genomic Drivers of Coronary Artery Disease and Risk of Future Outcomes After Coronary Angiography.

ABSTRACT:

Importance

Disease characteristics of genetically mediated coronary artery disease (CAD) on coronary angiography and the association of genomic risk with outcomes after coronary angiography are not well understood.

Objective

To assess the angiographic characteristics and risk of post-coronary angiography outcomes of patients with genomic drivers of CAD: familial hypercholesterolemia (FH), high polygenic risk score (PRS), and clonal hematopoiesis of indeterminate potential (CHIP).

Design, setting, and participants

A retrospective cohort study of 3518 Mass General Brigham Biobank participants with genomic information who underwent coronary angiography was conducted between July 18, 2000, and August 1, 2023.

Exposures

The presence of a genomic risk factor of CAD,

SUBMITTER: Supriami K 

PROVIDER: S-EPMC11751748 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature