Association between use of sodium-glucose co-transporter-2 inhibitor and the risk of incident dementia: a population-based cohort study.

ABSTRACT:

Objectives

To assess the association between sodium-glucose co-transporter-2 inhibitor (SGLT-2i) use and the risk of incident dementia compared with dipeptidyl peptidase-4 inhibitors (DPP-4i) use among individuals with type 2 diabetes.

Design

A population-based retrospective cohort study.

Setting

The Clinical Practice Research Datalink (CPRD) Aurum database from the UK.

Participants

Individuals with type 2 diabetes, aged 40 years or older, newly prescribed SGLT-2i or DPP-4i on or after 2013-2021, registered in the CPRD Aurum database.

Main outcome measure

The primary outcome was incident dementia, and the secondary outcome was incident mild cognitive impairment (MCI). Cox proportional hazard models were used to estimate the HR and corresponding 95% CI fo

SUBMITTER: Abdullah Z 

PROVIDER: S-EPMC11751778 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature