Longitudinal associations of flare and damage accrual in patients with systemic lupus erythematosus.

ABSTRACT:

Objective

To estimate the prevalence of organ damage (damage) and flare and to examine longitudinal associations between flares and subsequent damage accrual, in patients with systemic lupus erythematosus (SLE).

Methods

Patients enrolled in the Asia Pacific Lupus Collaboration cohort with ≥3 years of prospectively captured data were studied. Flares were assessed at routine visits, while damage ((Systemic Lupus International Collaborating Clinics/American College of Rheumatology) Damage Index) was assessed annually. Multivariable, multifailure survival analyses were carried out to quantify the association between flares and damage accrual.

Results

1556 patients with SLE with a median (IQR) of 5.7 (3.9, 7.0) years of follow-up were studied. 39.5% (n=614) of patients had

SUBMITTER: Kandane-Rathnayake R 

PROVIDER: S-EPMC11751792 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature