Sleep profile in patients with septo-optic-pituitary dysplasia: protocol for a prospective cohort study.

ABSTRACT:

Introduction

Children with septo-optic-pituitary dysplasia (SOD) may experience a range of visual impairments and hormonal dysfunctions beyond developmental delay/intellectual disability. The literature describes sleep fragmentation, circadian rhythm disruptions and reduced sleep efficiency. These manifestations are believed to be closely linked to both structural and functional abnormalities associated with SOD, potentially disrupting the natural circadian rhythm. Both anomalies in midline brain structures and decreased visual input could potentially impact melatonin secretion, although a distinct melatonin profile for SOD patients has yet to be identified. Furthermore, the specific contribution of these factors to sleep disturbances in SOD remains unexplored. The aim of this stud

SUBMITTER: Pasca L 

PROVIDER: S-EPMC11751809 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature