Transcriptome Concordance Between Borderline Tumors and Endometrioid Carcinoma: An Integrative Genomic Analysis.

ABSTRACT:

Background

Borderline ovarian tumors (BOTs) differ from ovarian carcinomas in their clinical presentation and behavior, yet their molecular characteristics remain poorly understood. This study aims to address this gap by integrating whole-exome sequencing (WES) and RNA sequencing (RNA-seq) to compare BOTs with high-grade serous carcinoma (HGSC), endometrioid carcinoma (EC), and clear-cell carcinoma (CCC).

Objective

To elucidate the molecular features of BOTs and evaluate their similarities and differences in comparison to HGSC, EC, and CCC.

Methods

The study analyzed 44 ovarian tumor samples, employing WES to identify genomic alterations and RNA-seq to examine transcriptomic profiles. Comparative analyses were conducted to investigate the molecular relationships among

SUBMITTER: Takahashi M 

PROVIDER: S-EPMC11751852 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature